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81.
Rajiv K. Bedi Dr. Danzhi Huang Stefanie A. Eberle Dr. Lars Wiedmer Dr. Pawel Śledź Prof. Amedeo Caflisch 《ChemMedChem》2020,15(9):744-748
The RNA methylase METTL3 catalyzes the transfer of a methyl group from the cofactor S-adenosyl-L-methionine (SAM) to the N6 atom of adenine. We have screened a library of 4000 analogues and derivatives of the adenosine moiety of SAM by high-throughput docking into METTL3. Two series of adenine derivatives were identified in silico, and the binding mode of six of the predicted inhibitors was validated by protein crystallography. Two compounds, one for each series, show good ligand efficiency. We propose a route for their further development into potent and selective inhibitors of METTL3. 相似文献
82.
Xiuhui Huang Junfeng Li Jun Wang Zeqiu Li Jiayin Xu 《Frontiers of Chemical Science and Engineering》2020,14(4):534
In the last decades, many reports dealing with technology for the catalytic combustion of methane (CH4) have been published. Recently, attention has increasingly focused on the synthesis and catalytic activity of nickel oxides. In this paper, a NiO/CeO2 catalyst with high catalytic performance in methane combustion was synthesized via a facile impregnation method, and its catalytic activity, stability, and water-resistance during CH4 combustion were investigated. X-ray diffraction, low-temperature N2 adsorption, thermogravimetric analysis, Fourier transform infrared spectroscopy, hydrogen temperature programmed reduction, methane temperature programmed surface reaction, Raman spectroscopy, electron paramagnetic resonance, and transmission electron microscope characterization of the catalyst were conducted to determine the origin of its high catalytic activity and stability in detail. The incorporation of NiO was found to enhance the concentration of oxygen vacancies, as well as the activity and amount of surface oxygen. As a result, the mobility of bulk oxygen in CeO2 was increased. The presence of CeO2 prevented the aggregation of NiO, enhanced reduction by NiO, and provided more oxygen species for the combustion of CH4. The results of a kinetics study indicated that the reaction order was about 1.07 for CH4 and about 0.10 for O2 over the NiO/CeO2 catalyst. 相似文献
83.
Liqiang Ren Shujie Yang Peiran Zhang Zhiguo Qu Zhangming Mao Po‐Hsun Huang Yuchao Chen Mengxi Wu Lin Wang Peng Li Tony Jun Huang 《Small (Weinheim an der Bergstrasse, Germany)》2018,14(40)
Microfluidic fluorescence‐activated cell sorters (μFACS) have attracted considerable interest because of their ability to identify and separate cells in inexpensive and biosafe ways. Here a high‐performance μFACS is presented by integrating a standing surface acoustic wave (SSAW)‐based, 3D cell‐focusing unit, an in‐plane fluorescent detection unit, and an SSAW‐based cell‐deflection unit on a single chip. Without using sheath flow or precise flow rate control, the SSAW‐based cell‐focusing technique can focus cells into a single file at a designated position. The tight focusing of cells enables an in‐plane‐integrated optical detection system to accurately distinguish individual cells of interest. In the acoustic‐based cell‐deflection unit, a focused interdigital transducer design is utilized to deflect cells from the focused stream within a minimized area, resulting in a high‐throughput sorting ability. Each unit is experimentally characterized, respectively, and the integrated SSAW‐based FACS is used to sort mammalian cells (HeLa) at different throughputs. A sorting purity of greater than 90% is achieved at a throughput of 2500 events s?1. The SSAW‐based FACS is efficient, fast, biosafe, biocompatible and has a small footprint, making it a competitive alternative to more expensive, bulkier traditional FACS. 相似文献
84.
Li Lanhui Lv Tiejun Huang Pingmu Mathiopoulos P. Takis 《Journal of Signal Processing Systems》2020,92(12):1421-1435
Journal of Signal Processing Systems - For vehicles with limited computation resources offloading their computational tasks to a mobile edge computing (MEC) server has been studied in the past as... 相似文献
85.
Nader Tehrani Dan Gallagher Monica Ponce de Leon Harry Lowd Richard Lee Lisa Huang Remon Alberts Janghwan Cheon Jumanah Jamal Aishah Al Sager 《世界建筑导报》2018,(2)
正Banq餐厅位是一家新型餐厅,位于便士储蓄银行(Penny Savings Bank)旧大楼以前用来经营银行业务的大厅内。餐厅分成两个部分,前面区域面向华盛顿大街,设计成酒吧,后面的大厅则作为用餐区。然而,这个空间在z轴上以天花板和地面之间的另一个分区为中心进行设计。如果由于餐厅空间活动的多变性而需要保持灵活性——包括两个座位、四个座位和六个座位,以及与聚会和其他活动有关的座位 相似文献
86.
87.
To improve the convertibility of reconfigurable manufacturing system (RMS), the concept of delayed reconfigurable manufacturing system (D-RMS) was proposed. RMS and D-RMS are both constructed around part family. However, D-RMS may suffer from ultra-long system problem with unacceptable idle machines using generic RMS part families. Besides, considering the complex basic system structure of D-RMS, machine selection of D-RMS should be addressed, including dedicated machine, flexible machine, and reconfigurable machine. Therefore, a system design method for D-RMS based on part family grouping and machine selection is proposed. Firstly, a part family grouping method is proposed for D-RMS that groups the parts with more former common operations into the same part family. The concept of longest relative position common operation subsequence (LPCS) is proposed. The similarity coefficient among the parts is calculated based on LPCS. The reciprocal value of the operation position of LPCS is adopted as the characteristic value. The average linkage clustering (ALC) algorithm is used to cluster the parts. Secondly, a machine selection method is proposed to complete the system design of D-RMS, including machine selection rules and the dividing point decision model. Finally, a case study is given to implement and verify the proposed system design method for D-RMS. The results show that the proposed system design method is effective, which can group parts with more former common operations into the same part family and select appropriate machine types. 相似文献
88.
To solve the special requirements of the high orbit optical remote sensing-satellite for the thermal deformation of the platform, the thermal deformation test and measurement scheme of the satellite platform is designed. Through the comparative analysis of test results, the rationality of the thermal deformation design of the platform structure is verified. The results of thermal deformation measurement show that the maximum deformation of A camera mounting surface is 57.5~〃, and the maximum deformation of B camera mounting surface points to 79.3~〃, which can be used as the basis for thermal deformation prediction of satellite during the orbit operation. 相似文献
89.
90.